Biphasic changes in ß-cell mass around parturition are accompanied by increased serotonin production.
Sci Rep
; 10(1): 4962, 2020 03 18.
Article
in En
| MEDLINE
| ID: mdl-32188885
ABSTRACT
Pancreatic ß-cell mass is known to be considerably altered during pregnancy and after parturition in rodents and humans. While ß-cell mass increases during pregnancy and starts to return toward its original level after parturition, the cellular mechanisms by which ß-cell mass during this period is regulated remains unclear. To address this issue in mice, we quantified ß-cell mass and investigated the mechanisms underlying its regulation throughout the perinatal and postpartum period. The increased ß-cell size and proliferation during pregnancy were significantly reduced shortly after parturition, whereas there was no evidence of ß-cell reprogramming or increased apoptosis. Direct RNA sequencing of islets from pregnant and postpartum mice demonstrated dynamic changes in gene expression patterns, showing robust downregulation of cell cycle-related genes 1 day after parturition, and the reupregulation of serotonin metabolism-related genes at postpartum day 7. Serotonin synthesis was activated only in lactating females, accompanied by increased ß-cell mass. Taken together, these findings demonstrate that ß-cell mass is decreased shortly after parturition owing to reduced ß-cell size and proliferation, and is subsequently increased, in association with lactation and serotonin biosynthesis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lactation
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Serotonin
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Parturition
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Insulin-Secreting Cells
Limits:
Adult
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Animals
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Female
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Humans
/
Pregnancy
Language:
En
Journal:
Sci Rep
Year:
2020
Document type:
Article
Affiliation country: