Host-Range Shift Between Emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains.
J Infect Dis
; 222(5): 836-839, 2020 08 04.
Article
in En
| MEDLINE
| ID: mdl-32188998
ABSTRACT
In Tunisia, we observed that rotavirus P[8]-3 and P[4] strains in young children with gastroenteritis associate with secretor histo-blood group phenotype. In contrast, the emerging P[8]-4 strain, representing 10% of cases, was exclusively found in nonsecretor patients. Unlike VP8* from P[8]-3 and P[4] strains, the P[8]-4 VP8* protein attached to glycans from saliva samples regardless of the donor's secretor status. Interestingly, a high frequency of FUT2 enzyme deficiency (nonsecretor phenotype) was observed in the population. This may allow cocirculation of P[8]-3 and P[8]-4 strains in secretor and nonsecretor children, respectively.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rotavirus Infections
/
RNA-Binding Proteins
/
Viral Nonstructural Proteins
/
Rotavirus
/
Host Specificity
/
Fucosyltransferases
Limits:
Child, preschool
/
Humans
/
Infant
/
Newborn
Language:
En
Journal:
J Infect Dis
Year:
2020
Document type:
Article
Affiliation country: