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Ruthenium(II)-Catalyzed Double Annulation of Quinones: Step-Economical Access to Valuable Bioactive Compounds.
da Silva Júnior, Eufrânio N; de Carvalho, Renato L; Almeida, Renata G; Rosa, Luisa G; Fantuzzi, Felipe; Rogge, Torben; Costa, Pedro M S; Pessoa, Claudia; Jacob, Claus; Ackermann, Lutz.
Affiliation
  • da Silva Júnior EN; Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077, Göttingen, Germany.
  • de Carvalho RL; Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, UFMG, 31270-901, Belo Horizonte, MG, Brazil.
  • Almeida RG; Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077, Göttingen, Germany.
  • Rosa LG; Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, UFMG, 31270-901, Belo Horizonte, MG, Brazil.
  • Fantuzzi F; Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, UFMG, 31270-901, Belo Horizonte, MG, Brazil.
  • Rogge T; Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, UFMG, 31270-901, Belo Horizonte, MG, Brazil.
  • Costa PMS; Institute for Inorganic Chemistry, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074, Würzburg, Germany.
  • Pessoa C; Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077, Göttingen, Germany.
  • Jacob C; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, 60430-270, Brazil.
  • Ackermann L; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, 60430-270, Brazil.
Chemistry ; 26(48): 10981-10986, 2020 Aug 26.
Article in En | MEDLINE | ID: mdl-32212283
ABSTRACT
Double ruthenium(II)-catalyzed alkyne annulations of quinones were accomplished. Thus, a strategy is reported that provides step-economical access to valuable quinones with a wide range of applications. C-H/N-H activations for alkyne annulations of naphthoquinones provided challenging polycyclic quinoidal compounds by forming four new bonds in one step. The singular power of the thus-obtained compounds was reflected by their antileukemic activity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinones / Ruthenium Type of study: Health_economic_evaluation Limits: Humans Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinones / Ruthenium Type of study: Health_economic_evaluation Limits: Humans Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: