Identification of a novel fusion gene, TRIM52-RACK1, in oral squamous cell carcinoma.
Mol Cell Probes
; 52: 101568, 2020 08.
Article
in En
| MEDLINE
| ID: mdl-32251686
ABSTRACT
Gene fusion is caused by the linkage of previously separate genes or sequences. Recently, an increasing number of novel fusion genes have been identified and associated with tumor progression, and several of them have been suggested as promising targets for tumor therapy. However, there are hardly any studies reporting the association of fusion genes with the progression of oral squamous cell carcinoma (OSCC). In this study, we identified a total of 11 fused genes in OSCC cells. We further analyzed the structure of one fused gene, TRIM52-RACK1, and detected its function in tumor progression in vitro. We found that TRIM52-RACK1 was caused by a deletion of 181,257,187-181,247,386 at 5q35.3 and it promoted OSCC cell proliferation, migration, and invasion. Therefore, TRIM52-RACK1 can be a promising target for tumor therapy in OSCC.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mouth Neoplasms
/
Carcinoma, Squamous Cell
/
Oncogene Proteins, Fusion
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Mol Cell Probes
Journal subject:
BIOLOGIA MOLECULAR
/
BIOTECNOLOGIA
Year:
2020
Document type:
Article
Affiliation country: