Inhibition of TET1 prevents the development of osteoarthritis and reveals the 5hmC landscape that orchestrates pathogenesis.

Smeriglio, Piera; Grandi, Fiorella C; Davala, Spoorthi; Masarapu, Venkata; Indelli, Pier Francesco; Goodman, Stuart B; Bhutani, Nidhi

Smeriglio, Piera; Grandi, Fiorella C; Davala, Spoorthi; Masarapu, Venkata; Indelli, Pier Francesco; Goodman, Stuart B; Bhutani, Nidhi.

Affiliation

Smeriglio P; Department of Orthopaedic Surgery, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Grandi FC; Department of Orthopaedic Surgery, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Davala S; Boston University, Boston, MA 02215, USA.
Masarapu V; Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA.
Indelli PF; Department of Orthopaedic Surgery, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Goodman SB; Department of Orthopaedic Surgery, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Bhutani N; Department of Orthopaedic Surgery, School of Medicine, Stanford University, Stanford, CA 94305, USA. nbhutani@stanford.edu.

Sci Transl Med ; 12(539)2020 04 15.

Article in En | MEDLINE | ID: mdl-32295898

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Pharmaceutical Preparations / Proto-Oncogene Proteins / DNA-Binding Proteins / Mixed Function Oxygenases Type of study: Etiology_studies Limits: Animals Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2020 Document type: Article Affiliation country: Country of publication:

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