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Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists.
Harikrishnan, Lalgudi S; Gill, Patrice; Kamau, Muthoni G; Qin, Lan-Ying; Ruan, Zheming; O'Malley, Daniel; Huynh, Tram; Stachura, Sylwia; Cavallaro, Cullen L; Lu, Zhonghui; J-W Duan, James; Weigelt, Carolyn A; Sack, John S; Ruzanov, Max; Khan, Javed; Gururajan, Murali; Wong, Jessica J; Huang, Yanling; Yarde, Melissa; Li, Zhuyin; Chen, Cliff; Sun, Huadong; Borowski, Virna; Murtaza, Anwar; Fink, Brian E.
Affiliation
  • Harikrishnan LS; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA. Electronic address: lalgudi.harikrishnan@bms.com.
  • Gill P; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Kamau MG; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Qin LY; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Ruan Z; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • O'Malley D; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Huynh T; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Stachura S; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Cavallaro CL; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Lu Z; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • J-W Duan J; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Weigelt CA; Molecular Structure & Design, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Sack JS; Molecular Structure & Design, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Ruzanov M; Molecular Structure & Design, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Khan J; Molecular Structure & Design, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Gururajan M; Immuno-Oncology Small Molecule Biology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Wong JJ; Immuno-Oncology Small Molecule Biology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Huang Y; Immuno-Oncology Small Molecule Biology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Yarde M; Lead Discovery & Optimization, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Li Z; Lead Discovery & Optimization, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Chen C; Preclinical Candidate Optimization, MAP, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Sun H; Preclinical Candidate Optimization, MAP, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Borowski V; In vivo Pharmacology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Murtaza A; In vivo Pharmacology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Fink BE; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
Bioorg Med Chem Lett ; 30(12): 127204, 2020 06 15.
Article in En | MEDLINE | ID: mdl-32334911
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzyl Compounds / Receptors, Retinoic Acid / Heterocyclic Compounds Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzyl Compounds / Receptors, Retinoic Acid / Heterocyclic Compounds Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Document type: Article Country of publication: