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Two unusual dendrobine-type alkaloids from Dendrobium findlayanum.
Yang, Dan; Cheng, Zhong-Quan; Hou, Bo; Yang, Liu; Zi, Cheng-Ting; Dong, Fa-Wu; Hu, Jiang-Miao; Zhou, Jun.
Affiliation
  • Yang D; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Guilin Medical University, Guilin 541199, China; Guangxi Normal University, Guilin 541004, China.
  • Cheng ZQ; Guilin Medical University, Guilin 541199, China.
  • Hou B; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
  • Yang L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
  • Zi CT; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
  • Dong FW; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
  • Hu JM; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: hujiangmiao@mail.kib.ac.cn.
  • Zhou J; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
Fitoterapia ; 144: 104607, 2020 Jul.
Article in En | MEDLINE | ID: mdl-32387373
ABSTRACT
Two unusual dendrobine-type alkaloids, findlayines E and F (1, 2), along with five known dendrobine-type alkaloids (3-7), were isolated from the stems of Dendrobium findlayanum Par. et Rchb. f. Compound 1 is the first example of dendrobine-type alkaloids with a 2-ethoxy-2-oxoethyl group attaching to the C-2, and compound 2 is a nor-dendrobine-type alkaloid, featuring a 5-decarboxylated structure. The structures of compounds 1 and 2 were elucidated by means of extensive spectroscopic analyses, and their absolute configuration were confirmed by electronic circular dichroism (ECD) calculations. All isolates were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549 and MCF-7 human cancer cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Stems / Dendrobium / Alkaloids Limits: Humans Country/Region as subject: Asia Language: En Journal: Fitoterapia Year: 2020 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Stems / Dendrobium / Alkaloids Limits: Humans Country/Region as subject: Asia Language: En Journal: Fitoterapia Year: 2020 Document type: Article Affiliation country: