Two unusual dendrobine-type alkaloids from Dendrobium findlayanum.
Fitoterapia
; 144: 104607, 2020 Jul.
Article
in En
| MEDLINE
| ID: mdl-32387373
ABSTRACT
Two unusual dendrobine-type alkaloids, findlayines E and F (1, 2), along with five known dendrobine-type alkaloids (3-7), were isolated from the stems of Dendrobium findlayanum Par. et Rchb. f. Compound 1 is the first example of dendrobine-type alkaloids with a 2-ethoxy-2-oxoethyl group attaching to the C-2, and compound 2 is a nor-dendrobine-type alkaloid, featuring a 5-decarboxylated structure. The structures of compounds 1 and 2 were elucidated by means of extensive spectroscopic analyses, and their absolute configuration were confirmed by electronic circular dichroism (ECD) calculations. All isolates were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549 and MCF-7 human cancer cells.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plant Stems
/
Dendrobium
/
Alkaloids
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Fitoterapia
Year:
2020
Document type:
Article
Affiliation country: