Your browser doesn't support javascript.
loading
Molecular and evolutionary analysis of dengue virus serotype 2 isolates from Korean travelers in 2015.
Hwang, Eun-Ha; Kim, Green; Oh, Hanseul; An, You Jung; Kim, Jiyeon; Kim, Jung Heon; Hwang, Eung-Soo; Park, Jong-Hwan; Hong, JungJoo; Koo, Bon-Sang.
Affiliation
  • Hwang EH; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea.
  • Kim G; Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea.
  • Oh H; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea.
  • An YJ; Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea.
  • Kim J; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea.
  • Kim JH; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea.
  • Hwang ES; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Park JH; Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul, Republic of Korea.
  • Hong J; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Koo BS; Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul, Republic of Korea.
Arch Virol ; 165(8): 1739-1748, 2020 Aug.
Article in En | MEDLINE | ID: mdl-32409874
ABSTRACT
In Korea, dengue infection has been frequently reported in travelers to tropical and subtropical countries. Global warming increases the probability of autochthonous dengue outbreaks in Korea. In this report, the molecular and evolutionary properties of four dengue virus (DENV) type 2 isolates from Korean overseas travelers were examined. Three of these isolates were classified as Cosmopolitan genotypes and further divided into sublineages 1 (43,253, 43,254) and 2 (43,248), while the other isolate (KBPV-VR29) was related to American genotypes. The variable amino acid motifs related to virulence and replication were identified in the structural and non-structural proteins. A negative selection mechanism was clearly verified in all of the DENV proteins. Potential recombination events were identified in the NS5 protein of the XSBN10 strain. The substitution rate (5.32 × 10-4 substitutions per site) and the time of the most recent common ancestor (TMRCA) for each evolutionary group were determined by the Bayesian skyline coalescent method. This study shows that DENV type 2 strains with distinct phylogenetic, evolutionary, and virulence characteristics have been introduced into Korea by overseas travelers and have the potential to trigger autochthonous dengue outbreaks.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dengue Virus Limits: Humans Country/Region as subject: Asia Language: En Journal: Arch Virol Year: 2020 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dengue Virus Limits: Humans Country/Region as subject: Asia Language: En Journal: Arch Virol Year: 2020 Document type: Article