[Mutltifaceted biological roles of leptin]. / Rôles biologiques à multiples facettes de la leptine.
Ann Biol Clin (Paris)
; 78(3): 231-242, 2020 06 01.
Article
in Fr
| MEDLINE
| ID: mdl-32540812
ABSTRACT
The identification of leptin allowed the discovery of a new endocrine system. This major adipokine controlling energy homeostasis is also involved in the regulation of neuroendocrine function and fertility. Unfortunately, leptin is not able to treat common obesity, which associates hyperleptinemia and resistance to the hormone. Conversely, treatment with recombinant leptin is effective in situations of leptin deficiency. Several pathophysiological situations associated with adipose tissue dysfunctions and abnormal regulation of leptin secretion are discussed in this review. The advantage of the potential use of the leptin assay in some pathophysiological conditions is proposed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leptin
Limits:
Animals
/
Humans
Language:
Fr
Journal:
Ann Biol Clin (Paris)
Year:
2020
Document type:
Article
Affiliation country: