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Falsely decreased thyroglobulin levels in a patient with differentiated thyroid carcinoma.
Hillebrand, J J; Siegelaar, S E; Heijboer, A C.
Affiliation
  • Hillebrand JJ; Amsterdam UMC, University of Amsterdam, Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam, the Netherlands. Electronic address: j.j.hillebrand@amsterdamumc.nl.
  • Siegelaar SE; Amsterdam UMC, University of Amsterdam, Department of Endocrinology & Metabolism, Amsterdam, the Netherlands.
  • Heijboer AC; Amsterdam UMC, University of Amsterdam, Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam, the Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology & Metabolism, Amsterdam, the Netherlands.
Clin Chim Acta ; 509: 217-219, 2020 Oct.
Article in En | MEDLINE | ID: mdl-32561346
We describe a case of a patient with metastasized differentiated thyroid carcinoma who was treated with total thyroidectomy followed-up by radioactive iodine treatment. During treatment and follow-up the thyroglobulin levels were assayed which surprisingly did not match the clinical condition. An analytical flaw was suspected. Re-analysis in the laboratory showed the presence of a high dose hook effect (HDH), resulting in falsely low Tg levels. This case shows that HDH effects in immunoassays, like the thyroglobulin assay, still exist in daily practice. Discordance between laboratory results and clinical condition underlines the importance of short lines of communication between clinical chemists and medical doctors.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thyroglobulin / Thyroid Neoplasms Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies Limits: Humans Language: En Journal: Clin Chim Acta Year: 2020 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thyroglobulin / Thyroid Neoplasms Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies Limits: Humans Language: En Journal: Clin Chim Acta Year: 2020 Document type: Article Country of publication: