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Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition.
Dzama, Margarita M; Steiner, Marlene; Rausch, Johanna; Sasca, Daniel; Schönfeld, Jonas; Kunz, Kerstin; Taubert, Martha C; McGeehan, Gerard M; Chen, Chun-Wei; Mupo, Annalisa; Hähnel, Patricia; Theobald, Matthias; Kindler, Thomas; Koche, Richard P; Vassiliou, George S; Armstrong, Scott A; Kühn, Michael W M.
Affiliation
  • Dzama MM; Department of Hematology, Medical Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • Steiner M; Department of Hematology, Medical Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • Rausch J; German Consortia for Translational Cancer Research, Mainz, Germany.
  • Sasca D; Department of Hematology, Medical Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • Schönfeld J; German Consortia for Translational Cancer Research, Mainz, Germany.
  • Kunz K; Department of Hematology, Medical Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • Taubert MC; German Consortia for Translational Cancer Research, Mainz, Germany.
  • McGeehan GM; University Cancer Center Mainz, Mainz, Germany.
  • Chen CW; Department of Hematology, Medical Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • Mupo A; Department of Hematology, Medical Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • Hähnel P; Department of Hematology, Medical Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • Theobald M; Syndax Pharmaceuticals, Inc, Waltham, MA.
  • Kindler T; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA.
  • Koche RP; Welcome-Medical Research Center (MRC) Cambridge Stem Cell Institute, Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
  • Vassiliou GS; Wellcome Sanger Institute, Cambridge, United Kingdom.
  • Armstrong SA; Department of Hematology, Medical Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • Kühn MWM; University Cancer Center Mainz, Mainz, Germany.
Blood ; 136(21): 2442-2456, 2020 11 19.
Article in En | MEDLINE | ID: mdl-32589720
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Antineoplastic Combined Chemotherapy Protocols / Gene Expression Regulation, Leukemic / Histone-Lysine N-Methyltransferase / Proto-Oncogene Proteins / Protein Kinase Inhibitors / Fms-Like Tyrosine Kinase 3 / Myeloid-Lymphoid Leukemia Protein / Neoplasm Proteins Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Humans Language: En Journal: Blood Year: 2020 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Antineoplastic Combined Chemotherapy Protocols / Gene Expression Regulation, Leukemic / Histone-Lysine N-Methyltransferase / Proto-Oncogene Proteins / Protein Kinase Inhibitors / Fms-Like Tyrosine Kinase 3 / Myeloid-Lymphoid Leukemia Protein / Neoplasm Proteins Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Humans Language: En Journal: Blood Year: 2020 Document type: Article Affiliation country: Country of publication: