Undefeated-Changing the phenamacril scaffold is not enough to beat resistant Fusarium.
PLoS One
; 15(6): e0235568, 2020.
Article
in En
| MEDLINE
| ID: mdl-32598376
ABSTRACT
Filamentous fungi belonging to the genus Fusarium are notorious plant-pathogens that infect, damage and contaminate a wide variety of important crops. Phenamacril is the first member of a novel class of single-site acting cyanoacrylate fungicides which has proven highly effective against important members of the genus Fusarium. However, the recent emergence of field-resistant strains exhibiting qualitative resistance poses a major obstacle for the continued use of phenamacril. In this study, we synthesized novel cyanoacrylate compounds based on the phenamacril-scaffold to test their growth-inhibitory potential against wild-type Fusarium and phenamacril-resistant strains. Our findings show that most chemical modifications to the phenamacril-scaffold are associated with almost complete loss of fungicidal activity and in vitro inhibition of myosin motor domain ATPase activity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cyanoacrylates
/
Drug Resistance, Fungal
/
Fungicides, Industrial
/
Fusarium
Type of study:
Qualitative_research
Language:
En
Journal:
PLoS One
Journal subject:
CIENCIA
/
MEDICINA
Year:
2020
Document type:
Article
Affiliation country: