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Impact of Antiplatelet and Anticoagulant Therapies on Platelet-related Prognostic Markers in Patients With Esophageal Cancer.
Ishibashi, Yusuke; Tsujimoto, Hironori; Kouzu, Keita; Itazaki, Yujiro; Tsuchiya, Satoshi; Fujishima, Seiichiro; Yaguchi, Yoshihisa; Sugasawa, Hidekazu; Nomura, Shinsuke; Ito, Nozomi; Harada, Manabu; Nagata, Hiromi; Shinto, Eiji; Kishi, Yoji; Ueno, Hideki.
Affiliation
  • Ishibashi Y; Department of Surgery, National Defense Medical College, Saitama, Japan.
  • Tsujimoto H; Department of Surgery, National Defense Medical College, Saitama, Japan tsujihi@ndmc.ac.jp.
  • Kouzu K; Department of Surgery, National Defense Medical College, Saitama, Japan.
  • Itazaki Y; Department of Surgery, National Defense Medical College, Saitama, Japan.
  • Tsuchiya S; Department of Surgery, National Defense Medical College, Saitama, Japan.
  • Fujishima S; Department of Surgery, National Defense Medical College, Saitama, Japan.
  • Yaguchi Y; Department of Surgery, National Defense Medical College, Saitama, Japan.
  • Sugasawa H; Department of Surgery, National Defense Medical College, Saitama, Japan.
  • Nomura S; Department of Surgery, National Defense Medical College, Saitama, Japan.
  • Ito N; Department of Surgery, National Defense Medical College, Saitama, Japan.
  • Harada M; Department of Surgery, National Defense Medical College, Saitama, Japan.
  • Nagata H; Department of Surgery, National Defense Medical College, Saitama, Japan.
  • Shinto E; Department of Surgery, National Defense Medical College, Saitama, Japan.
  • Kishi Y; Department of Surgery, National Defense Medical College, Saitama, Japan.
  • Ueno H; Department of Surgery, National Defense Medical College, Saitama, Japan.
In Vivo ; 34(4): 1941-1949, 2020.
Article in En | MEDLINE | ID: mdl-32606166
ABSTRACT
BACKGROUND/

AIM:

In recent years, platelet-related markers were recognized as useful prognostic factors in various malignancies. We investigated the relationship between platelet-related prognostic markers and anti-platelet or anti-coagulant therapies for survival outcomes in esophageal squamous cell carcinoma. PATIENTS AND

METHODS:

Preoperative platelet-related prognostic markers were evaluated from peripheral blood testing and statistical analyses were performed to evaluate the prognostic value of these markers and reveal the effects of antiplatelets and/or anticoagulants regarding their prognostic relevance.

RESULTS:

In all 176 patients, preoperative platelet-to-lymphocyte ratio (PLR) was not found to be a predictor of overall survival (OS). However, in patients without antiplatelet or anticoagulant therapies, PLR was significantly associated with a poor OS (p=0.03). Although platelet large cell ratio (P-LCR) was not associated with the prognosis in patients with antiplatelet and/or anticoagulant therapies, higher P-LCR was associated with a poor prognosis in patients without antiplatelet or anticoagulant therapies (p<0.0001).

CONCLUSION:

Researching detailed antiplatelet and anticoagulant therapies could reinforce the prognostic value of platelet-related prognostic markers in ESCC.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Esophageal Neoplasms / Carcinoma, Squamous Cell / Esophageal Squamous Cell Carcinoma Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: In Vivo Journal subject: NEOPLASIAS Year: 2020 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Esophageal Neoplasms / Carcinoma, Squamous Cell / Esophageal Squamous Cell Carcinoma Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: In Vivo Journal subject: NEOPLASIAS Year: 2020 Document type: Article Affiliation country: