Is There Any Association Between Mammographic Features of Microcalcifications and Breast Cancer Subtypes in Ductal Carcinoma In Situ?
Acad Radiol
; 28(7): 963-968, 2021 07.
Article
in En
| MEDLINE
| ID: mdl-32620528
ABSTRACT
RATIONALE AND OBJECTIVES:
To analyze the association between mammographic features of microcalcifications and histopathological prognostic factors based on estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2/neu) in ductal carcinoma in situ (DCIS). MATERIALS ANDMETHODS:
We retrospectively determined 66 patients with microcalcification-associated pure DCIS. Distribution and morphological features of the microcalcifications were described using Breast Imaging Reporting and Data System lexicon. All patients were divided into three subgroups ER-positive, HER-2 positive, and triple-negative according to the immunohistochemical findings.RESULTS:
The morphological features of microcalcifications and receptor subtypes were significantly correlated (pâ¯=â¯0.026). Fine pleomorphic and fine linear branching microcalcifications were observed in 85.2% of HER-2 positive cases, whereas this ratio was 71.4 % in ER-positive and 25% in the triple-negative group. Fine linear branching microcalcifications with linear or segmental distribution were more frequently found with comedo necrosis (p < 0.05). Larger tumour sizes were also associated with microcalcification distribution (p < 0.001). Segmental microcalcifications more likely associated with larger tumour sizes.CONCLUSION:
Mammographic features in DCIS correlated with immunohistochemical and histopathological prognostic factors.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Calcinosis
/
Carcinoma, Ductal, Breast
/
Carcinoma, Intraductal, Noninfiltrating
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Acad Radiol
Journal subject:
RADIOLOGIA
Year:
2021
Document type:
Article