A Microfluidic Human Model of Blood-Brain Barrier Employing Primary Human Astrocytes.
Adv Biosyst
; 3(7): e1800335, 2019 07.
Article
in En
| MEDLINE
| ID: mdl-32648668
ABSTRACT
The neurovascular unit (NVU) is the most important biological barrier between vascular districts and central nervous system (CNS) parenchyma, which maintains brain homeostasis, protects the CNS from pathogens penetration, and mediates neuroimmune communication. T lymphocytes migration across the blood-brain barrier is heavily affected in different brain diseases, representing a major target for novel drug development. In vitro models of NVU could represent a primary tool to investigate the molecular events occurring at this interface. To move toward the establishment of personalized therapies, a patient-related NVU-model is set, incorporating human primary astrocytes integrated into a microfluidic platform. The model is morphologically and functionally characterized, proving to be an advantageous tool to investigate human T lymphocytes transmigration and thus the efficacy of potential novel drugs affecting this process.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood-Brain Barrier
/
Astrocytes
/
Microfluidic Analytical Techniques
/
Models, Cardiovascular
/
Models, Neurological
Limits:
Humans
Language:
En
Journal:
Adv Biosyst
Year:
2019
Document type:
Article
Affiliation country: