Biomolecular Corona Affects Controlled Release of Drug Payloads from Nanocarriers.
Trends Pharmacol Sci
; 41(9): 641-652, 2020 09.
Article
in En
| MEDLINE
| ID: mdl-32713606
ABSTRACT
Nanomedicine has been widely used for a wide range of biomedical applications including drug delivery. Although many factors including the physicochemical properties of nanoparticles (NPs) and the payload efficacy of nanocarriers have been thoroughly investigated, the crucial role of the biomolecular corona in drug delivery and the release efficacy of nanocarriers demands further attention. This review highlights not only the crucial importance of the biomolecular corona to the drug release capacity of various types of nanocarriers, but also its interference with drug release measurements. A full consideration of the effects of the biomolecular corona on the controlled release and drug delivery of nanocarriers will help researchers design safer and more efficient nanobased drug delivery systems.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nanomedicine
/
Nanoparticles
Limits:
Humans
Language:
En
Journal:
Trends Pharmacol Sci
Year:
2020
Document type:
Article
Affiliation country: