Stochastic intracellular regulation can remove oscillations in a model of tissue growth.
Math Med Biol
; 37(4): 551-568, 2020 12 15.
Article
in En
| MEDLINE
| ID: mdl-32735317
ABSTRACT
The work is devoted to the analysis of cell population dynamics where cells make a choice between differentiation and apoptosis. This choice is based on the values of intracellular proteins whose concentrations are described by a system of ordinary differential equations with bistable dynamics. Intracellular regulation and cell fate are controlled by the extracellular regulation through the number of differentiated cells. It is shown that the total cell number necessarily oscillates if the initial condition in the intracellular regulation is fixed. These oscillations can be suppressed if the initial condition is a random variable with a sufficiently large variation. Thus, the result of the work suggests a possible answer to the question about the role of stochasticity in the intracellular regulation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Differentiation
/
Cell Physiological Phenomena
/
Apoptosis
/
Models, Biological
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Math Med Biol
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
2020
Document type:
Article
Affiliation country: