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PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma.
Sharma, Gaurav; Ojha, Rani; Noguera-Ortega, Estela; Rebecca, Vito W; Attanasio, John; Liu, Shujing; Piao, Shengfu; Lee, Jennifer J; Nicastri, Michael C; Harper, Sandra L; Ronghe, Amruta; Jain, Vaibhav; Winkler, Jeffrey D; Speicher, David W; Mastio, Jerome; Gimotty, Phyllis A; Xu, Xiaowei; Wherry, E John; Gabrilovich, Dmitry I; Amaravadi, Ravi K.
Affiliation
  • Sharma G; Abramson Cancer Center and Department of Medicine.
  • Ojha R; Abramson Cancer Center and Department of Medicine.
  • Noguera-Ortega E; Abramson Cancer Center and Department of Medicine.
  • Rebecca VW; Abramson Cancer Center and Department of Medicine.
  • Attanasio J; Department of Systems Pharmacology and Translational Therapeutics and Penn Institute for Immunology, and.
  • Liu S; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Piao S; Abramson Cancer Center and Department of Medicine.
  • Lee JJ; Abramson Cancer Center and Department of Medicine.
  • Nicastri MC; Department of Chemistry, College of Arts & Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Harper SL; Wistar Institute, Philadelphia, Pennsylvania, USA.
  • Ronghe A; Wistar Institute, Philadelphia, Pennsylvania, USA.
  • Jain V; Abramson Cancer Center and Department of Medicine.
  • Winkler JD; Department of Chemistry, College of Arts & Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Speicher DW; Wistar Institute, Philadelphia, Pennsylvania, USA.
  • Mastio J; Wistar Institute, Philadelphia, Pennsylvania, USA.
  • Gimotty PA; Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Xu X; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Wherry EJ; Department of Systems Pharmacology and Translational Therapeutics and Penn Institute for Immunology, and.
  • Gabrilovich DI; Wistar Institute, Philadelphia, Pennsylvania, USA.
  • Amaravadi RK; Abramson Cancer Center and Department of Medicine.
JCI Insight ; 5(17)2020 09 03.
Article in En | MEDLINE | ID: mdl-32780726

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiolester Hydrolases / Enzyme Inhibitors / Programmed Cell Death 1 Receptor / Immune Checkpoint Inhibitors / Hydroxychloroquine / Melanoma Type of study: Prognostic_studies Limits: Animals Language: En Journal: JCI Insight Year: 2020 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiolester Hydrolases / Enzyme Inhibitors / Programmed Cell Death 1 Receptor / Immune Checkpoint Inhibitors / Hydroxychloroquine / Melanoma Type of study: Prognostic_studies Limits: Animals Language: En Journal: JCI Insight Year: 2020 Document type: Article Country of publication: