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Indirect cell death and the LQ model in SBRT and SRS.
Song, Chang W; Terezakis, Stephanie; Emami, Bahman; Griffin, Robert J; Sperduto, Paul W; Kim, Mi-Sook; Cho, L Chinsoo.
Affiliation
  • Song CW; Department of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN, USA.
  • Terezakis S; Department of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN, USA.
  • Emami B; Department of Radiation Oncology, Loyola University Medical Center Chicago, IL, USA.
  • Griffin RJ; Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
  • Sperduto PW; Minneapolis Radiation Oncology and Gamma Knife Center, University of Minnesota, Minneapolis, MN, USA.
  • Kim MS; Department of Radiation Oncology, Korea Institute of Radiological & Medical Sciences, Seoul Korea.
  • Cho LC; Department of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN, USA.
J Radiosurg SBRT ; 7(1): 1-4, 2020.
Article in En | MEDLINE | ID: mdl-32802572
ABSTRACT
High-dose hypofractionated SBRT and SRS indirectly kills substantial fractions of tumor cells via causing vascular damage. The LQ formula may work well for certain clinical cases of SBRT and SRS when the indirect/additional tumor cell death secondary to vascular damage is small. However, when the indirect cell death is extensive, the LQ model will underestimate the clinical outcome of SBRT and SRS.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Radiosurg SBRT Year: 2020 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Radiosurg SBRT Year: 2020 Document type: Article Affiliation country: