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Targeted Radiosensitizers for MR-Guided Radiation Therapy of Prostate Cancer.
Luo, Dong; Johnson, Andrew; Wang, Xinning; Li, Hao; Erokwu, Bernadette O; Springer, Sarah; Lou, Jason; Ramamurthy, Gopalakrishnan; Flask, Chris A; Burda, Clemens; Meade, Thomas J; Basilion, James P.
Affiliation
  • Luo D; Department of Radiology, Case Western Reserve University, Cleveland, Ohio 44106, United States.
  • Johnson A; Department of Chemistry, Molecular Biosciences, Neurobiology, and Radiology, Northwestern University, Evanston, Illinois 60208, United States.
  • Wang X; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.
  • Li H; Department of Chemistry, Molecular Biosciences, Neurobiology, and Radiology, Northwestern University, Evanston, Illinois 60208, United States.
  • Erokwu BO; Department of Radiology, Case Western Reserve University, Cleveland, Ohio 44106, United States.
  • Springer S; Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States.
  • Lou J; Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States.
  • Ramamurthy G; Department of Radiology, Case Western Reserve University, Cleveland, Ohio 44106, United States.
  • Flask CA; Department of Radiology, Case Western Reserve University, Cleveland, Ohio 44106, United States.
  • Burda C; Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106, United States.
  • Meade TJ; Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States.
  • Basilion JP; Department of Chemistry, Molecular Biosciences, Neurobiology, and Radiology, Northwestern University, Evanston, Illinois 60208, United States.
Nano Lett ; 20(10): 7159-7167, 2020 10 14.
Article in En | MEDLINE | ID: mdl-32845644
ABSTRACT
Adjuvant radiotherapy is frequently prescribed to treat cancer. To minimize radiation-related damage to healthy tissue, it requires high precision in tumor localization and radiation dose delivery. This can be achieved by MR guidance and targeted amplification of radiation dose selectively to tumors by using radiosensitizers. Here, we demonstrate prostate cancer-targeted gold nanoparticles (AuNPs) for MR-guided radiotherapy to improve the targeting precision and efficacy. By conjugating Gd(III) complexes and prostate-specific membrane antigen (PSMA) targeting ligands to AuNP surfaces, we found enhanced uptake of AuNPs by PSMA-expressing cancer cells with excellent MR contrast and radiation therapy outcome in vitro and in vivo. The AuNPs binding affinity and r1 relaxivity were dramatically improved and the combination of Au and Gd(III)provided better tumor suppression after radiation. The precise tumor localization by MR and selective tumor targeting of the PSMA-1-targeted AuNPs could enable precise radiotherapy, reduction in irradiating dose, and minimization of healthy tissue damage.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Metal Nanoparticles Type of study: Guideline Limits: Humans / Male Language: En Journal: Nano Lett Year: 2020 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Metal Nanoparticles Type of study: Guideline Limits: Humans / Male Language: En Journal: Nano Lett Year: 2020 Document type: Article Affiliation country: