Circular DNA intermediates in the generation of large human segmental duplications.
BMC Genomics
; 21(1): 593, 2020 Aug 26.
Article
in En
| MEDLINE
| ID: mdl-32847497
ABSTRACT
BACKGROUND:
Duplications of large genomic segments provide genetic diversity in genome evolution. Despite their importance, how these duplications are generated remains uncertain, particularly for distant duplicated genomic segments.RESULTS:
Here we provide evidence of the participation of circular DNA intermediates in the single generation of some large human segmental duplications. A specific reversion of sequence order from A-B/C-D to B-A/D-C between duplicated segments and the presence of only microhomologies and short indels at the evolutionary breakpoints suggest a circularization of the donor ancestral locus and an accidental replicative interaction with the acceptor locus.CONCLUSIONS:
This novel mechanism of random genomic mutation could explain several distant genomic duplications including some of the ones that took place during recent human evolution.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA, Circular
/
Segmental Duplications, Genomic
Limits:
Humans
Language:
En
Journal:
BMC Genomics
Journal subject:
GENETICA
Year:
2020
Document type:
Article
Affiliation country: