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Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise.
Brandão, Bruna B; Madsen, Søren; Rabiee, Atefeh; Oliverio, Matteo; Ruiz, Gabriel P; Ferrucci, Danilo L; Branquinho, Jéssica L; Razolli, Daniela; Pinto, Silas; Nielsen, Thomas S; Festuccia, William T; Martins, Adriano S; Guerra, Beatriz A; Knittel, Thiago L; Søgaard, Ditte; Larsen, Steen; Helge, Jørn W; Brandauer, Josef; Velloso, Lício A; Emanuelli, Brice; Kornfeld, Jan-Wilhelm; Kahn, C Ronald; Vienberg, Sara G; Zierath, Juleen R; Treebak, Jonas T; Mori, Marcelo A.
Affiliation
  • Brandão BB; Program in Molecular Biology, Federal University of São Paulo, 04044-020 São Paulo, Brazil.
  • Madsen S; Department of Biophysics, Federal University of São Paulo, 04023-062 São Paulo, Brazil.
  • Rabiee A; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215.
  • Oliverio M; Integrative Metabolism and Environmental Influences, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Ruiz GP; Integrative Metabolism and Environmental Influences, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Ferrucci DL; Laboratory of Non-Coding Principles of Energy Homeostasis, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.
  • Branquinho JL; Research Area 1, Cologne Cluster of Excellence in Cellular Stress Responses in Ageing-Associated Diseases, 50931 Cologne, Germany.
  • Razolli D; Internal Medicin I, Apoptosis-Signaling and Therapy Resistance Group, University Hospital of Cologne, 50937 Cologne, Germany.
  • Pinto S; Program in Genetics and Molecular Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.
  • Nielsen TS; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.
  • Festuccia WT; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.
  • Martins AS; Program in Molecular Biology, Federal University of São Paulo, 04044-020 São Paulo, Brazil.
  • Guerra BA; Department of Biophysics, Federal University of São Paulo, 04023-062 São Paulo, Brazil.
  • Knittel TL; Obesity and Comorbidities Research Center, University of Campinas, 13083-862 Campinas, Brazil.
  • Søgaard D; Laboratory of Cell and Molecular Biology, São Francisco University, 12916-900 Bragança Paulista, Brazil.
  • Larsen S; Program in Genetics and Molecular Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.
  • Helge JW; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.
  • Brandauer J; Integrative Metabolism and Environmental Influences, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Velloso LA; Department of Physiology, Institute of Biomedical Sciences, University of São Paulo, 05508-000 São Paulo, Brazil.
  • Emanuelli B; Program in Molecular Biology, Federal University of São Paulo, 04044-020 São Paulo, Brazil.
  • Kornfeld JW; Department of Biophysics, Federal University of São Paulo, 04023-062 São Paulo, Brazil.
  • Kahn CR; Orthopedics Department, Maimonides Medical Center, Brooklyn, NY 11219.
  • Vienberg SG; Program in Molecular Biology, Federal University of São Paulo, 04044-020 São Paulo, Brazil.
  • Zierath JR; Department of Biophysics, Federal University of São Paulo, 04023-062 São Paulo, Brazil.
  • Treebak JT; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.
  • Mori MA; Program in Genetics and Molecular Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.
Proc Natl Acad Sci U S A ; 117(38): 23932-23941, 2020 09 22.
Article in En | MEDLINE | ID: mdl-32900951
ABSTRACT
DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body metabolic adaptations to aerobic exercise training, in part, by allowing controlled substrate utilization in adipose tissue, which, in turn, supports skeletal muscle function. Exercise training increases overall miRNA expression in adipose tissue, and up-regulation of miR-203-3p limits glycolysis in adipose under conditions of metabolic stress. We propose that exercise training-induced DICER-miR-203-3p up-regulation in adipocytes is a key adaptive response that coordinates signals from working muscle to promote whole-body metabolic adaptations.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Exercise / Adipose Tissue / Ribonuclease III / DEAD-box RNA Helicases Limits: Animals / Female / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Exercise / Adipose Tissue / Ribonuclease III / DEAD-box RNA Helicases Limits: Animals / Female / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Document type: Article Affiliation country: