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Optical coherence tomography for thyroid pathology: 3D analysis of tissue microstructure.
Emil Tampu, Iulian; Maintz, Michaela; Koller, Daniela; Johansson, Kenth; Gimm, Oliver; Capitanio, Arrigo; Eklund, Anders; Haj-Hosseini, Neda.
Affiliation
  • Emil Tampu I; Department of Biomedical Engineering, Linköping University, Linköping 581 85, Sweden.
  • Maintz M; Department of Biomedical Engineering, Linköping University, Linköping 581 85, Sweden.
  • Koller D; Department of Biomedical Engineering, Linköping University, Linköping 581 85, Sweden.
  • Johansson K; Department of Surgery, Västervik Hospital and Örebro University Hospital, Västervik and Örebro, Sweden.
  • Gimm O; Department of Surgery, and Department of Biomedical and Clinical Sciences, Linköping University Hospital and Linköping University, Linköping 581 85, Sweden.
  • Capitanio A; Department of Clinical Pathology, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping 581 85, Sweden.
  • Eklund A; Department of Biomedical Engineering, Linköping University, Linköping 581 85, Sweden.
  • Haj-Hosseini N; Division of Statistics & Machine Learning, Department of Computer and Information Science, Linköping University, Linköping 581 83, Sweden.
Biomed Opt Express ; 11(8): 4130-4149, 2020 Aug 01.
Article in En | MEDLINE | ID: mdl-32923033
ABSTRACT
To investigate the potential of optical coherence tomography (OCT) to distinguish between normal and pathologic thyroid tissue, 3D OCT images were acquired on ex vivo thyroid samples from adult subjects (n=22) diagnosed with a variety of pathologies. The follicular structure was analyzed in terms of count, size, density and sphericity. Results showed that OCT images highly agreed with the corresponding histopatology and the calculated parameters were representative of the follicular structure variation. The analysis of OCT volumes provides quantitative information that could make automatic classification possible. Thus, OCT can be beneficial for intraoperative surgical guidance or in the pathology assessment routine.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Guideline Language: En Journal: Biomed Opt Express Year: 2020 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Guideline Language: En Journal: Biomed Opt Express Year: 2020 Document type: Article Affiliation country: