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Design, synthesis and biological evaluation of thieno[3,2-d]pyrimidine derivatives containing aroyl hydrazone or aryl hydrazide moieties for PI3K and mTOR dual inhibition.
Han, Yufei; Tian, Ye; Wang, Ruxin; Fu, Siyu; Jiang, Jia; Dong, Jiawen; Qin, Mingze; Hou, Yunlei; Zhao, Yanfang.
Affiliation
  • Han Y; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Tian Y; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Wang R; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Fu S; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Jiang J; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Dong J; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Qin M; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China; Chinese People's Liberation Army Logistics Support Force No. 967 Hospital, Dalian 116021, China.
  • Hou Y; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China; Yangtze River Pharmaceutical Group Pharmaceutical Co., Ltd, 1 South Yangtze River Road Taizhou, Jiangsu 225321, China. Ele
  • Zhao Y; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. Electronic address: yanfangzhao@126.com.
Bioorg Chem ; 104: 104197, 2020 11.
Article in En | MEDLINE | ID: mdl-32927132

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Phosphatidylinositol 3-Kinases / Protein Kinase Inhibitors / TOR Serine-Threonine Kinases / Hydrazines / Hydrazones / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Chem Year: 2020 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Phosphatidylinositol 3-Kinases / Protein Kinase Inhibitors / TOR Serine-Threonine Kinases / Hydrazines / Hydrazones / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Chem Year: 2020 Document type: Article Affiliation country: Country of publication: