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Two new steroidal alkaloids from the rhizomes of Veratrum nigrum L. and their anti-TYLCV activity.
Li, Yu-Lin; Zhang, Yu; Zhao, Ping-Zhi; Hu, Zhan-Xing; Gu, Yu-Cheng; Ye, Jian; Hao, Xiao-Jiang.
Affiliation
  • Li YL; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Zhang Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
  • Zhao PZ; State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
  • Hu ZX; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Gu YC; Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK.
  • Ye J; State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: jianye@im.ac.cn.
  • Hao XJ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: haoxj@mail.kib.ac.cn.
Fitoterapia ; 147: 104731, 2020 Nov.
Article in En | MEDLINE | ID: mdl-32979466
ABSTRACT
Two new steroidal alkaloids (1-2), together with seven known related steroidal alkaloids (3-9), were isolated from the rhizomes of Veratrum nigrum L. Their structures were elucidated by extensive spectroscopic analysis, and by comparison with literature data. Compound 1 possessed a rare 1, 3-oxazolidine unit within varazine-type alkaloids, and 2 was a 9-hydroxy-4-one derivative of 3-veratroylgermine. All isolates were evaluated inhibit tomato yellow leaf curl virus (TYLCV) activity. Compounds 5 and 7 (40 µg/mL) showed a significant anti-TYLCV activity in the host Nicotiana benthamiana with inhibition rates 74.6% and 63.4%, respectively, which are higher than that of the positive control ningnanmycin (51.4%).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Diseases / Steroids / Veratrum / Alkaloids / Begomovirus Country/Region as subject: Asia Language: En Journal: Fitoterapia Year: 2020 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Diseases / Steroids / Veratrum / Alkaloids / Begomovirus Country/Region as subject: Asia Language: En Journal: Fitoterapia Year: 2020 Document type: Article Affiliation country: