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Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance.
Aschenbrenner, Dominik; Quaranta, Maria; Banerjee, Soumya; Ilott, Nicholas; Jansen, Joanneke; Steere, Boyd; Chen, Yin-Huai; Ho, Stephen; Cox, Karen; Arancibia-Cárcamo, Carolina V; Coles, Mark; Gaffney, Eamonn; Travis, Simon Pl; Denson, Lee; Kugathasan, Subra; Schmitz, Jochen; Powrie, Fiona; Sansom, Stephen N; Uhlig, Holm H.
Affiliation
  • Aschenbrenner D; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, University of Oxford, Oxford, Oxfordshire, UK.
  • Quaranta M; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, University of Oxford, Oxford, Oxfordshire, UK.
  • Banerjee S; IBD Center, Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Milan, Italy.
  • Ilott N; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, University of Oxford, Oxford, Oxfordshire, UK.
  • Jansen J; Department of Psychology, University of Cambridge, Cambridge, Cambridgeshire, UK.
  • Steere B; Kennedy Institute of Rheumatology, University of Oxford, Oxford, Oxfordshire, UK.
  • Chen YH; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, University of Oxford, Oxford, Oxfordshire, UK.
  • Ho S; Wolfson Centre for Mathematical Biology, University of Oxford, Oxford, Oxfordshire, UK.
  • Cox K; Immunology Translational Sciences, Eli Lilly and Company, Indianapolis, Indiana, USA.
  • Arancibia-Cárcamo CV; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, University of Oxford, Oxford, Oxfordshire, UK.
  • Coles M; Immunology Translational Sciences, Eli Lilly and Company, Indianapolis, Indiana, USA.
  • Gaffney E; Immunology Translational Sciences, Eli Lilly and Company, Indianapolis, Indiana, USA.
  • Travis SP; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, University of Oxford, Oxford, Oxfordshire, UK.
  • Denson L; Kennedy Institute of Rheumatology, University of Oxford, Oxford, Oxfordshire, UK.
  • Kugathasan S; Wolfson Centre for Mathematical Biology, University of Oxford, Oxford, Oxfordshire, UK.
  • Schmitz J; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, University of Oxford, Oxford, Oxfordshire, UK.
  • Powrie F; Pediatric Gastroenterology, Cincinnati Childrens Hospital Medical Center, Cincinnati, Ohio, USA.
  • Sansom SN; Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Uhlig HH; Immunology Translational Sciences, Eli Lilly and Company, Indianapolis, Indiana, USA.
Gut ; 70(6): 1023-1036, 2021 06.
Article in En | MEDLINE | ID: mdl-33037057
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Resistance / Monocytes / Inflammatory Bowel Diseases / Interleukin-10 / Interleukin-23 Subunit p19 Type of study: Prognostic_studies Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Gut Year: 2021 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Resistance / Monocytes / Inflammatory Bowel Diseases / Interleukin-10 / Interleukin-23 Subunit p19 Type of study: Prognostic_studies Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Gut Year: 2021 Document type: Article Affiliation country: