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Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin.
Espinet, Elisa; Gu, Zuguang; Imbusch, Charles D; Giese, Nathalia A; Büscher, Magdalena; Safavi, Mariam; Weisenburger, Silke; Klein, Corinna; Vogel, Vanessa; Falcone, Mattia; Insua-Rodríguez, Jacob; Reitberger, Manuel; Thiel, Vera; Kossi, Steffi O; Muckenhuber, Alexander; Sarai, Karnjit; Lee, Alex Y L; Backx, Elyne; Zarei, Soheila; Gaida, Matthias M; Rodríguez-Paredes, Manuel; Donato, Elisa; Yen, Hsi-Yu; Eils, Roland; Schlesner, Matthias; Pfarr, Nicole; Hackert, Thilo; Plass, Christoph; Brors, Benedikt; Steiger, Katja; Weichenhan, Dieter; Arda, H Efsun; Rooman, Ilse; Kopp, Janel L; Strobel, Oliver; Weichert, Wilko; Sprick, Martin R; Trumpp, Andreas.
Affiliation
  • Espinet E; HI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany. a.trumpp@dkfz.de e.espinet@dkfz.de.
  • Gu Z; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.
  • Imbusch CD; German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Giese NA; Bioinformatics and Omics Data Analytics, DKFZ, Heidelberg, Germany.
  • Büscher M; Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany.
  • Safavi M; Division of Applied Bioinformatics, DKFZ and NCT, Heidelberg, Germany.
  • Weisenburger S; Department of General and Visceral Surgery, University Hospital Heidelberg, Heidelberg, Germany.
  • Klein C; HI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
  • Vogel V; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.
  • Falcone M; HI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
  • Insua-Rodríguez J; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.
  • Reitberger M; HI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
  • Thiel V; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.
  • Kossi SO; HI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
  • Muckenhuber A; HI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
  • Sarai K; HI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
  • Lee AYL; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.
  • Backx E; HI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
  • Zarei S; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.
  • Gaida MM; HI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
  • Rodríguez-Paredes M; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.
  • Donato E; HI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
  • Yen HY; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.
  • Eils R; HI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
  • Schlesner M; Institute of Pathology, Technical University of Munich, Munich, Germany.
  • Pfarr N; Department of Cellular and Physiological Sciences, Life Science Institute, University of British Columbia, Vancouver, British Columbia, Canada.
  • Hackert T; Department of Cellular and Physiological Sciences, Life Science Institute, University of British Columbia, Vancouver, British Columbia, Canada.
  • Plass C; Laboratory of Molecular and Medical Oncology, Vrije Universiteit Brussel, Brussels, Belgium.
  • Brors B; Department of Cellular and Physiological Sciences, Life Science Institute, University of British Columbia, Vancouver, British Columbia, Canada.
  • Steiger K; Institute of Pathology, University Hospital of Heidelberg, Heidelberg, Germany.
  • Weichenhan D; Institute of Pathology, University Medical Center JGU Mainz, Mainz, Germany.
  • Arda HE; Division of Epigenetics, DKFZ-ZMBH Alliance, DKFZ, Heidelberg, Germany.
  • Rooman I; HI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
  • Kopp JL; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.
  • Strobel O; Institute of Pathology, Technical University of Munich, Munich, Germany.
  • Weichert W; Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany.
  • Sprick MR; Digital Health Centre, Berlin Institute of Health and Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Trumpp A; Health Data Science Unit, University Hospital and University of Heidelberg, Heidelberg, Germany.
Cancer Discov ; 11(3): 638-659, 2021 03.
Article in En | MEDLINE | ID: mdl-33060108
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Repetitive Sequences, Nucleic Acid / Interferons / DNA Methylation / Carcinoma, Pancreatic Ductal Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cancer Discov Year: 2021 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Repetitive Sequences, Nucleic Acid / Interferons / DNA Methylation / Carcinoma, Pancreatic Ductal Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cancer Discov Year: 2021 Document type: Article