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Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics.
Hillisch, Alexander; Gericke, Kersten M; Allerheiligen, Swen; Roehrig, Susanne; Schaefer, Martina; Tersteegen, Adrian; Schulz, Simone; Lienau, Philip; Gnoth, Mark; Puetter, Vera; Hillig, Roman C; Heitmeier, Stefan.
Affiliation
  • Hillisch A; Research and Development, Bayer AG, Pharmaceuticals, 42103 Wuppertal, Germany.
  • Gericke KM; Research and Development, Bayer AG, Pharmaceuticals, 42103 Wuppertal, Germany.
  • Allerheiligen S; Research and Development, Bayer AG, Pharmaceuticals, 42103 Wuppertal, Germany.
  • Roehrig S; Research and Development, Bayer AG, Pharmaceuticals, 42103 Wuppertal, Germany.
  • Schaefer M; Research and Development, Bayer AG, Pharmaceuticals, 13342 Berlin, Germany.
  • Tersteegen A; Research and Development, Bayer AG, Pharmaceuticals, 42103 Wuppertal, Germany.
  • Schulz S; Research and Development, Bayer AG, Pharmaceuticals, 42103 Wuppertal, Germany.
  • Lienau P; Research and Development, Bayer AG, Pharmaceuticals, 13342 Berlin, Germany.
  • Gnoth M; Research and Development, Bayer AG, Pharmaceuticals, 42103 Wuppertal, Germany.
  • Puetter V; Research and Development, Bayer AG, Pharmaceuticals, 13342 Berlin, Germany.
  • Hillig RC; Research and Development, Bayer AG, Pharmaceuticals, 13342 Berlin, Germany.
  • Heitmeier S; Research and Development, Bayer AG, Pharmaceuticals, 42103 Wuppertal, Germany.
J Med Chem ; 63(21): 12574-12594, 2020 11 12.
Article in En | MEDLINE | ID: mdl-33108181

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombin / Drug Design / Anticoagulants Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombin / Drug Design / Anticoagulants Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Country of publication: