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Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint.
Floudas, Achilleas; Neto, Nuno; Marzaioli, Viviana; Murray, Kieran; Moran, Barry; Monaghan, Michael G; Low, Candice; Mullan, Ronan H; Rao, Navin; Krishna, Vinod; Nagpal, Sunil; Veale, Douglas J; Fearon, Ursula.
Affiliation
  • Floudas A; Molecular Rheumatology, Trinity Biomedical Sciences Institute.
  • Neto N; Department of Mechanical and Manufacturing Engineering, and.
  • Marzaioli V; Trinity Centre for Biomedical Engineering, Trinity College Dublin, Dublin, Ireland.
  • Murray K; Molecular Rheumatology, Trinity Biomedical Sciences Institute.
  • Moran B; EULAR Centre of Excellence, Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital, University College Dublin, Dublin, Ireland.
  • Monaghan MG; EULAR Centre of Excellence, Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital, University College Dublin, Dublin, Ireland.
  • Low C; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Mullan RH; Department of Mechanical and Manufacturing Engineering, and.
  • Rao N; Trinity Centre for Biomedical Engineering, Trinity College Dublin, Dublin, Ireland.
  • Krishna V; EULAR Centre of Excellence, Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital, University College Dublin, Dublin, Ireland.
  • Nagpal S; Department of Rheumatology, Tallaght University Hospital, Dublin, Ireland.
  • Veale DJ; Janssen Research & Development, Immunology, Spring House, Pennsylvania, USA.
  • Fearon U; Janssen Research & Development, Immunology, Spring House, Pennsylvania, USA.
JCI Insight ; 5(21)2020 11 05.
Article in En | MEDLINE | ID: mdl-33148884
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Synovial Membrane / B-Lymphocytes / Programmed Cell Death 1 Receptor / Glycolysis / Inflammation / Hypoxia Type of study: Observational_studies / Risk_factors_studies Limits: Humans Language: En Journal: JCI Insight Year: 2020 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Synovial Membrane / B-Lymphocytes / Programmed Cell Death 1 Receptor / Glycolysis / Inflammation / Hypoxia Type of study: Observational_studies / Risk_factors_studies Limits: Humans Language: En Journal: JCI Insight Year: 2020 Document type: Article Country of publication: