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Study Protocol for Teen Inflammation Glutamate Emotion Research (TIGER).
Walker, Johanna C; Teresi, Giana I; Weisenburger, Rachel L; Segarra, Jillian R; Ojha, Amar; Kulla, Artenisa; Sisk, Lucinda; Gu, Meng; Spielman, Daniel M; Rosenberg-Hasson, Yael; Maecker, Holden T; Singh, Manpreet K; Gotlib, Ian H; Ho, Tiffany C.
Affiliation
  • Walker JC; Department of Psychology, Stanford University, Stanford, CA, United States.
  • Teresi GI; Department of Psychology, Stanford University, Stanford, CA, United States.
  • Weisenburger RL; Department of Psychology, Stanford University, Stanford, CA, United States.
  • Segarra JR; Department of Psychology, Stanford University, Stanford, CA, United States.
  • Ojha A; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, United States.
  • Kulla A; Department of Psychology, Stanford University, Stanford, CA, United States.
  • Sisk L; Department of Psychology, Yale University, New Haven, CT, United States.
  • Gu M; Department of Radiology, Stanford University, Stanford, CA, United States.
  • Spielman DM; Department of Radiology, Stanford University, Stanford, CA, United States.
  • Rosenberg-Hasson Y; Department of Electrical Engineering, Stanford University, Stanford, CA, United States.
  • Maecker HT; Human Immune Monitoring Center, Stanford University, Stanford, CA, United States.
  • Singh MK; Department of Microbiology and Immunology, Stanford University, Stanford, CA, United States.
  • Gotlib IH; Human Immune Monitoring Center, Stanford University, Stanford, CA, United States.
  • Ho TC; Department of Microbiology and Immunology, Stanford University, Stanford, CA, United States.
Front Hum Neurosci ; 14: 585512, 2020.
Article in En | MEDLINE | ID: mdl-33192421
This article provides an overview of the study protocol for the Teen Inflammation Glutamate Emotion Research (TIGER) project, a longitudinal study in which we plan to recruit 60 depressed adolescents (ages 13-18 years) and 30 psychiatrically healthy controls in order to examine the inflammatory and glutamatergic pathways that contribute to the recurrence of depression in adolescents. TIGER is the first study to examine the effects of peripheral inflammation on neurodevelopmental trajectories by assessing changes in cortical glutamate in depressed adolescents. Here, we describe the scientific rationale, design, and methods for the TIGER project. This article is intended to serve as an introduction to this project and to provide details for investigators who may be seeking to replicate or extend these methods for other related research endeavors.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Observational_studies Language: En Journal: Front Hum Neurosci Year: 2020 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Observational_studies Language: En Journal: Front Hum Neurosci Year: 2020 Document type: Article Affiliation country: Country of publication: