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Erythrocyte Alloimmunity and Genetic Variance: Results from the Collaborative Study of Alloimmunity to Antigen Diversity in Asian Populations (All ADP).
Takeshita, Akihiro; Watanabe, Hiroko; Yamada, Chiaki; Nadarajan, Veera Sekaran; Permpikul, Parichart; Sinkitjasub, Attapong; Natalie, Chan Pui Ha; Zhao, Shuming; Han, Kyou Sup; Kim, Dae Won; Suh, Jang Soo; Kim, Hyun Ok; Kawabata, Kinuyo; Ishimaru, Ken; Ohtomo, Naoki; Yamada, Naotomo; Tomoda, Yutaka; Yurugi, Kimiko; Ohto, Hitoshi.
Affiliation
  • Takeshita A; Transfusion and Cell Therapy, Hamamatsu University School of Medicine, Hamamatsu, Japan. Electronic address: akihirot@hama-med.ac.jp.
  • Watanabe H; Transfusion and Cell Therapy, Hamamatsu University School of Medicine, Hamamatsu, Japan.
  • Yamada C; Transfusion and Cell Therapy, Hamamatsu University School of Medicine, Hamamatsu, Japan.
  • Nadarajan VS; Transfusion Medicine, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
  • Permpikul P; Transfusion Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
  • Sinkitjasub A; Blood Bank, Taksin Hospital, Medical Service Department of Bangkok Metropolitan, Bangkok, Thailand.
  • Natalie CPH; Blood Bank, Prince of Wales Hospital, Hong Kong Special Administrative Region.
  • Zhao S; Transfusion Medicine, Southwest Hospital, Third Military Medical University, Chongqing, China.
  • Han KS; Seegene Medical Foundation, Seoul, South Korea.
  • Kim DW; Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Soul, South Korea.
  • Suh JS; Laboratory Medicine, Kyungpook National University Hospital, Kyungpook National University, School of Medicine, Daegu, South Korea.
  • Kim HO; Laboratory Medicine, Yonsei University College of Medicine, Soul, South Korea.
  • Kawabata K; Blood Transfusion and Transplantation Immunology, Fukushima Medical University, Fukushima, Japan.
  • Ishimaru K; Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.
  • Ohtomo N; Center for Transfusion Medicine and Cell Therapy, Tokyo Medical and Dental University, Tokyo, Japan.
  • Yamada N; Department of Transfusion Medicine, Saga University, Saga, Japan.
  • Tomoda Y; Laboratory Medicine, Asahikawa Medical University, Asahikawa, Japan.
  • Yurugi K; Clinical Laboratory, Kyoto University Hospital, Kyoto, Japan.
  • Ohto H; Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.
Transfus Apher Sci ; 59(5): 102944, 2020 Oct.
Article in En | MEDLINE | ID: mdl-33228922
ABSTRACT
As an East-Asian international study, we evaluated erythrocyte alloimmunity by gender and history of transfusion or pregnancy. In total, data from more than 1,826,000 patients were analyzed, from whom 26,170 irregular erythrocyte antibodies were detected in 22,653 cases. Antibody frequencies in these cases were as follows anti-E, 26.8%; anti-Lea, 20.0%; anti-P1, 7.1%; anti-M, 6.4%; anti-Mia, 5.6%; anti-c + E, 5.6%; anti-Leb, 4.6%; anti-D, 2.8%; anti-Fyb, 2.6%; anti-Lea+Leb, 2.5%; anti-Dia, 2.0%; and others. For pregnant patients, anti-D (12.7%) was statistically more frequent. For transfused patients, anti-E (37.3%), anti-c + E (9.5%), anti-C + e (3.3%) and anti-Jka (3.1%) were significantly more frequent.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Variation / Erythrocytes / Isoantibodies Limits: Female / Humans / Male / Pregnancy Language: En Journal: Transfus Apher Sci Journal subject: HEMATOLOGIA Year: 2020 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Variation / Erythrocytes / Isoantibodies Limits: Female / Humans / Male / Pregnancy Language: En Journal: Transfus Apher Sci Journal subject: HEMATOLOGIA Year: 2020 Document type: Article