[The role of three-dimensional chromatin structure changes in tumor progression].
Zhonghua Wai Ke Za Zhi
; 58(12): 973-976, 2020 Dec 01.
Article
in Zh
| MEDLINE
| ID: mdl-33249814
ABSTRACT
The human genome is not a linear structure, but a three-dimensional structure through complex folding and assembly. Chromosome structure capture technology can detect the three-dimensional construction of chromatin. Hi-C sequencing data of various tumors indicate that the chromatin topology associated domains changed during tumor progression and is related to copy number variation. In addition, transformation of the genomic compartment is related to gene expression. However, current researches on three-dimensional structures of tumoral chromatin are still in the stage of exploration, and some conclusions are too superficial to be applied to the clinic immediately, which requires further study.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromatin
/
DNA Copy Number Variations
/
Molecular Conformation
/
Neoplasms
Limits:
Humans
Language:
Zh
Journal:
Zhonghua Wai Ke Za Zhi
Year:
2020
Document type:
Article
Affiliation country: