Environmental pollutants induce noninherited antibiotic resistance to polymyxin B in Escherichia coli.
Future Microbiol
; 15: 1631-1643, 2020 11.
Article
in En
| MEDLINE
| ID: mdl-33251814
ABSTRACT
Aim:
The mechanisms behind antibiotic resistance by bacteria are important to create alternative molecules.Objective:
This study focuses on the impact of environmental pollutants on bacterial resistance to antibiotics. Materials &methods:
The effect of various environmental pollutants on noninherited bacterial resistance to antibiotics was examined.Results:
The tolerance to the polymyxin-B antibiotic was shown to be conferred to Escherichia coli, by pretreatment with subinhibitory concentrations of environmental toxicants. The cell survival to a sublethal dosage of antibiotics was tested. Exposure to low concentrations of toxic compounds (500 ppb copper, 2% [v/v] ethanol or 0.5 µg/ml trimethoprim) stimulated the bacterial heat shock systems and led to increased tolerance to polymyxin B.Conclusion:
Environmental pollutants induce a temporary bacterial noninheritable resistance to antibiotic.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polymyxin B
/
Drug Resistance, Bacterial
/
Environmental Pollutants
/
Escherichia coli
/
Anti-Bacterial Agents
Language:
En
Journal:
Future Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2020
Document type:
Article
Affiliation country: