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Targeting the ion channel TRPM7 promotes the thymic development of regulatory T cells by promoting IL-2 signaling.
Mendu, Suresh K; Stremska, Marta E; Schappe, Michael S; Moser, Emily K; Krupa, Julia K; Rogers, Jason S; Stipes, Eric J; Parker, Clare A; Braciale, Thomas J; Perry, Justin S A; Desai, Bimal N.
Affiliation
  • Mendu SK; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
  • Stremska ME; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
  • Schappe MS; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.
  • Moser EK; Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Krupa JK; University of Florida, Gainesville, FL 32610, USA.
  • Rogers JS; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
  • Stipes EJ; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
  • Parker CA; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
  • Braciale TJ; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
  • Perry JSA; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.
  • Desai BN; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Sci Signal ; 13(661)2020 12 08.
Article in En | MEDLINE | ID: mdl-33293462
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymus Gland / Signal Transduction / Interleukin-2 / T-Lymphocytes, Regulatory / TRPM Cation Channels Limits: Animals Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2020 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymus Gland / Signal Transduction / Interleukin-2 / T-Lymphocytes, Regulatory / TRPM Cation Channels Limits: Animals Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2020 Document type: Article Affiliation country: