[Progress in research of Fusobacterium nucleatum and upper gastrointestinal cancer].
Zhonghua Liu Xing Bing Xue Za Zhi
; 41(11): 1938-1941, 2020 Nov 10.
Article
in Zh
| MEDLINE
| ID: mdl-33297665
ABSTRACT
With the development of multi-omics and high throughput sequencing technology, studies have shown that the disorder of microbiota is related to various cancers. Nevertheless, the research on the relationship between upper digestive tract cancer or precancerous lesions and gastrointestinal microecology is still less. Fusobacterium nucleatum, one of the oral symbiotic bacteria, is also an opportunistic pathogen, which can promote the formation of tumor microenvironment and can be used as a new biomarker for the early detection and early diagnosis of cancer. In this study, by searching CNKI, Wanfang data, PubMed and Embase databases, it was found that the abundance of F. nucleatum in cancer tissues is higher than that in paracancerous tissues and associated with poor prognosis. The research of relationship between F. nucleatum and precancerous lesions needs to be carried out urgently. In addition, the types of specimens, sequencing technology, strain subtypes, carcinogenic mechanism and other directions still need to be explored.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fusobacterium nucleatum
/
Gastrointestinal Neoplasms
Type of study:
Screening_studies
Limits:
Humans
Language:
Zh
Journal:
Zhonghua Liu Xing Bing Xue Za Zhi
Year:
2020
Document type:
Article
Affiliation country: