Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia.
Elife
; 92020 12 17.
Article
in En
| MEDLINE
| ID: mdl-33331820
ABSTRACT
Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient's persistent symptoms and radiological changes.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pseudomonas Infections
/
Lymphocyte Activation
/
T-Lymphocytes
/
Pneumonia, Ventilator-Associated
/
SARS-CoV-2
/
COVID-19
/
Anti-Bacterial Agents
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Elife
Year:
2020
Document type:
Article
Affiliation country: