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Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.
Kim, Sung-Hoon; Choi, Jung-Hyun; Wang, Peng; Go, Christopher D; Hesketh, Geoffrey G; Gingras, Anne-Claude; Jafarnejad, Seyed Mehdi; Sonenberg, Nahum.
Affiliation
  • Kim SH; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3A 1A3, Canada.
  • Choi JH; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3A 1A3, Canada.
  • Wang P; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3A 1A3, Canada.
  • Go CD; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada.
  • Hesketh GG; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada.
  • Gingras AC; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada.
  • Jafarnejad SM; Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast BT9 7AE, UK. Electronic address: sm.jafarnejad@qub.ac.uk.
  • Sonenberg N; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3A 1A3, Canada. Electronic address: nahum.sonenberg@mcgill.ca.
Mol Cell ; 81(2): 398-407.e4, 2021 01 21.
Article in En | MEDLINE | ID: mdl-33340489
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Threonine / Threonine-tRNA Ligase / Monomeric GTP-Binding Proteins / Mechanistic Target of Rapamycin Complex 1 / Mitochondria Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2021 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Threonine / Threonine-tRNA Ligase / Monomeric GTP-Binding Proteins / Mechanistic Target of Rapamycin Complex 1 / Mitochondria Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2021 Document type: Article Affiliation country: