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Effects of choral singing versus health education on cognitive decline and aging: a randomized controlled trial.
Feng, Lei; Romero-Garcia, Rafael; Suckling, John; Tan, Jasmine; Larbi, Anis; Cheah, Irwin; Wong, Glenn; Tsakok, Maurine; Lanskey, Bernard; Lim, Darius; Li, Jialiang; Yang, Joanna; Goh, Benjamin; Teck, Tristan Gwee Chen; Ho, Allan; Wang, Xiu; Yu, Jin-Tai; Zhang, Can; Tan, Crystal; Chua, Michelle; Li, Junhua; Totman, John J; Wong, Caroline; Loh, Marie; Foo, Roger; Tan, Chay Hoon; Goh, Lee Gan; Mahendran, Rathi; Kennedy, Brian K; Kua, Ee-Heok.
Affiliation
  • Feng L; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Romero-Garcia R; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Suckling J; Centre for Healthy Longevity, National University Health System, Singapore, Singapore.
  • Tan J; Department of Psychiatry, University of Cambridge, UK.
  • Larbi A; Department of Psychiatry, University of Cambridge, UK.
  • Cheah I; Department of Psychology, Goldsmiths, University of London, UK.
  • Wong G; Biology of Aging Laboratory, Singapore Immunology Network, Singapore.
  • Tsakok M; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Lanskey B; Biology of Aging Laboratory, Singapore Immunology Network, Singapore.
  • Lim D; Maurine Tsakok Inc, Singapore.
  • Li J; Yong Siew Toh Conservatory of Music, National University of Singapore, Singapore.
  • Yang J; Darius Lim, Voices of Singapore Choral Society, Singapore.
  • Goh B; Department of Statistics and Applied Probability, Faculty of Science, National University of Singapore, Singapore.
  • Teck TGC; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Ho A; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Wang X; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Yu JT; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Zhang C; Presbyterian Community Services, Singapore.
  • Tan C; NTUC Health Co-operative Limited, Singapore.
  • Chua M; Beijing Chui Yang Liu Hospital, Beijing, PR China.
  • Li J; Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
  • Totman JJ; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
  • Wong C; Biology of Aging Laboratory, Singapore Immunology Network, Singapore.
  • Loh M; Biology of Aging Laboratory, Singapore Immunology Network, Singapore.
  • Foo R; School of Computer Science and Electronic Engineering, University of Essex, UK.
  • Tan CH; Clinical Imaging Research Centre, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Goh LG; Clinical Imaging Research Centre, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Mahendran R; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
  • Kennedy BK; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
  • Kua EH; Cardiovascular Research Institute, National University Health Systems, Singapore.
Aging (Albany NY) ; 12(24): 24798-24816, 2020 12 18.
Article in En | MEDLINE | ID: mdl-33346748
ABSTRACT
We conducted a randomized controlled trial to examine choral singing's effect on cognitive decline in aging. Older Singaporeans who were at high risk of future dementia were recruited 47 were assigned to choral singing intervention (CSI) and 46 were assigned to health education program (HEP). Participants attended weekly one-hour choral singing or weekly one-hour health education for two years. Change in cognitive function was measured by a composite cognitive test score (CCTS) derived from raw scores of neuropsychological tests; biomarkers included brain magnetic resonance imaging, oxidative damage and immunosenescence. The average age of the participants were 70 years and 73/93 (78.5%) were female. The change of CCTS from baseline to 24 months was 0.05 among participants in the CSI group and -0.1 among participants in the HEP group. The between-group difference (0.15, p=0.042) became smaller (0.12, p=0.09) after adjusting for baseline CCTS. No between-group differences on biomarkers were observed. Our data support the role of choral singing in improving cognitive health in aging. The beneficial effect is at least comparable than that of health education in preventing cognitive decline in a community of elderly people. Biological mechanisms underlying the observed efficacy should be further studied.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Cognitive Dysfunction / Singing / Music Therapy Type of study: Clinical_trials Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Aging (Albany NY) Journal subject: GERIATRIA Year: 2020 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Cognitive Dysfunction / Singing / Music Therapy Type of study: Clinical_trials Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Aging (Albany NY) Journal subject: GERIATRIA Year: 2020 Document type: Article Affiliation country: