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Synthesis of 2'-O-alkylcarbamoylethyl-modified oligonucleotides with enhanced nuclease resistance that form isostable duplexes with complementary RNA.
Kishimura, Tomohiro; Tomori, Takahito; Masaki, Yoshiaki; Seio, Kohji.
Affiliation
  • Kishimura T; Department of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.
  • Tomori T; Department of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.
  • Masaki Y; Department of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan; JST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan.
  • Seio K; Department of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan. Electronic address: kseio@bio.titech.ac.jp.
Bioorg Med Chem Lett ; 35: 127779, 2021 03 01.
Article in En | MEDLINE | ID: mdl-33434643
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides / RNA, Complementary / Enzyme Inhibitors / Exonucleases Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides / RNA, Complementary / Enzyme Inhibitors / Exonucleases Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Document type: Article Affiliation country: