Efficacy of novel bispecific antibody targeting TNF-&#945;/CXCL10 in the treatment of experimental arthritis.

Kang, Shin Eui; Park, Jin Kyun; Yoo, Hyun Jung; Kang, Heun-Soo; Park, Young Woo; Park, Bum-Chan; Park, Jae-Eun; Lee, Eun Young; Lee, Eun Bong; Song, Yeong Wook

Efficacy of novel bispecific antibody targeting TNF-α/CXCL10 in the treatment of experimental arthritis.

Kang, Shin Eui; Park, Jin Kyun; Yoo, Hyun Jung; Kang, Heun-Soo; Park, Young Woo; Park, Bum-Chan; Park, Jae-Eun; Lee, Eun Young; Lee, Eun Bong; Song, Yeong Wook.

Affiliation

Kang SE; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea; Division of Rheumatology, Department of Internal Medicine, Seoul National Unive
Park JK; Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Yoo HJ; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea; Division of Rheumatology, Department of Internal Medicine, Seoul National Unive
Kang HS; Cell2in,Inc., Seoul, Republic of Korea.
Park YW; Y-Biologics, Daejeon, Republic of Korea.
Park BC; Y-Biologics, Daejeon, Republic of Korea.
Park JE; Y-Biologics, Daejeon, Republic of Korea.
Lee EY; Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Lee EB; Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Song YW; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea; Division of Rheumatology, Department of Internal Medicine, Seoul National Unive

Transl Res ; 232: 75-87, 2021 06.

Article in En | MEDLINE | ID: mdl-33453429

Subject(s)
Key words

ADAâ¯=â¯adalimumab; ANOVAâ¯=â¯analysis of variance; BsAbâ¯=â¯bispecific antibody; CXCL10â¯=â¯C-X-C motif chemokine 10; FLSâ¯=â¯fibroblast-like synoviocytes; GAPDHâ¯=â¯glyceraldehyde 3-phosphate dehydrogenase; H&Eâ¯=â¯hematoxylin and eosin; IC(50)â¯=â¯the half-maximal inhibitory concentration; ILâ¯=â¯interleukin; Kdâ¯=â¯dissociation constants; LPSâ¯=â¯lipopolysaccharide; Mwâ¯=â¯molecular weight; O.D.â¯=â¯optical density; PBMCsâ¯=â¯peripheral blood mononuclear cells; PBSâ¯=â¯phosphate-buffered saline; RANKLâ¯=â¯receptor activator of nuclear factor kappa-B ligand; RAâ¯=â¯rheumatoid arthritis; SEMâ¯=â¯standard error of the mean; SPRâ¯=â¯surface plasmon resonance; ScFvâ¯=â¯single-chain variable fragment; TNF-αâ¯=â¯tumor necrosis factor-α; TRAPâ¯=â¯tartrate-resistant acid phosphatase; Tg mouseâ¯=â¯transgenic mouse; VHâ¯=â¯variable heavy chain; VLâ¯=â¯variable light chain; bDMARDsâ¯=â¯biological disease-modifying anti-rheumatic drugs; cDNAâ¯=â¯complementary DNA; qPCRâ¯=â¯quantitative real-time polymerase chain reaction

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Experimental / Arthritis, Rheumatoid / Tumor Necrosis Factor-alpha / Antibodies, Bispecific / Chemokine CXCL10 Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Transl Res Journal subject: MEDICINA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Year: 2021 Document type: Article

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google