Current status and future prospects of p38α/MAPK14 kinase and its inhibitors.
Eur J Med Chem
; 213: 113216, 2021 Mar 05.
Article
in En
| MEDLINE
| ID: mdl-33524689
ABSTRACT
P38α (which is also named MAPK14) plays a pivotal role in initiating different disease states such as inflammatory disorders, neurodegenerative diseases, cardiovascular cases, and cancer. Inhibitors of p38α can be utilized for treatment of these diseases. In this article, we reviewed the structural and biological characteristics of p38α, its relationship to the fore-mentioned disease states, as well as the recently reported inhibitors and classified them according to their chemical structures. We focused on the articles published in the literature during the last decade (2011-2020).
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mitogen-Activated Protein Kinase 14
/
Protein Kinase Inhibitors
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Eur J Med Chem
Year:
2021
Document type:
Article
Affiliation country: