Novel chimeric TLR2/NOD2 agonist CL429 exhibited significant radioprotective effects in mice.
J Cell Mol Med
; 25(8): 3785-3792, 2021 04.
Article
in En
| MEDLINE
| ID: mdl-33609010
ABSTRACT
Severe ionizing radiation causes the acute lethal damage of haematopoietic system and gastrointestinal tract. Here, we found CL429, the novel chimeric TLR2/NOD2 agonist, exhibited significant radioprotective effects in mice. CL429 increased mice survival, protected mice against the lethal damage of haematopoietic system and gastrointestinal tract. CL429 was more effective than equivalent amounts of monospecific (TLR2 or NOD2) and combination (TLR2 + NOD2) of molecules in preventing radiation-induced death. The radioprotection of CL429 was mainly mediated by activating TLR2 and partially activating NOD2. CL429-induced radioprotection was largely dependent on the activation of TLR2-MyD88-NF-κB signalling pathway. In conclusion, the data suggested that the co-activation of TLR2 and NOD2 could induce significant synergistic radioprotective effects and CL429 might be a potential high-efficiency selective agent.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Radiation-Protective Agents
/
Acetylmuramyl-Alanyl-Isoglutamine
/
Whole-Body Irradiation
/
Toll-Like Receptor 2
/
Nod2 Signaling Adaptor Protein
/
Acute Radiation Syndrome
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Hematopoietic System
/
Intestines
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
J Cell Mol Med
Journal subject:
BIOLOGIA MOLECULAR
Year:
2021
Document type:
Article
Affiliation country: