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Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.
Gharahkhani, Puya; Jorgenson, Eric; Hysi, Pirro; Khawaja, Anthony P; Pendergrass, Sarah; Han, Xikun; Ong, Jue Sheng; Hewitt, Alex W; Segrè, Ayellet V; Rouhana, John M; Hamel, Andrew R; Igo, Robert P; Choquet, Helene; Qassim, Ayub; Josyula, Navya S; Cooke Bailey, Jessica N; Bonnemaijer, Pieter W M; Iglesias, Adriana; Siggs, Owen M; Young, Terri L; Vitart, Veronique; Thiadens, Alberta A H J; Karjalainen, Juha; Uebe, Steffen; Melles, Ronald B; Nair, K Saidas; Luben, Robert; Simcoe, Mark; Amersinghe, Nishani; Cree, Angela J; Hohn, Rene; Poplawski, Alicia; Chen, Li Jia; Rong, Shi-Song; Aung, Tin; Vithana, Eranga Nishanthie; Tamiya, Gen; Shiga, Yukihiro; Yamamoto, Masayuki; Nakazawa, Toru; Currant, Hannah; Birney, Ewan; Wang, Xin; Auton, Adam; Lupton, Michelle K; Martin, Nicholas G; Ashaye, Adeyinka; Olawoye, Olusola; Williams, Susan E; Akafo, Stephen.
Affiliation
  • Gharahkhani P; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. Puya.Gharahkhani@qimrberghofer.edu.au.
  • Jorgenson E; Division of Research, Kaiser Permanente Northern California (KPNC), Oakland, CA, USA.
  • Hysi P; Twin Research and Genetic Epidemiology, King's College London, London, UK.
  • Khawaja AP; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
  • Pendergrass S; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Han X; Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA.
  • Ong JS; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Hewitt AW; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Segrè AV; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.
  • Rouhana JM; Centre for Eye Research Australia, University of Melbourne, Melbourne, VIC, Australia.
  • Hamel AR; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
  • Igo RP; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
  • Choquet H; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
  • Qassim A; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Josyula NS; Division of Research, Kaiser Permanente Northern California (KPNC), Oakland, CA, USA.
  • Cooke Bailey JN; Department of Ophthalmology, Flinders University, Bedford Park, SA, Australia.
  • Bonnemaijer PWM; Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA.
  • Iglesias A; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Siggs OM; Cleveland Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Young TL; Depatment of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.
  • Vitart V; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
  • Thiadens AAHJ; The Rotterdam Eye Hospital, Rotterdam, The Netherlands.
  • Karjalainen J; Depatment of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.
  • Uebe S; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
  • Melles RB; Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands.
  • Nair KS; Department of Ophthalmology, Flinders University, Bedford Park, SA, Australia.
  • Luben R; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.
  • Simcoe M; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Amersinghe N; Depatment of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.
  • Cree AJ; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
  • Hohn R; Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.
  • Poplawski A; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
  • Chen LJ; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Rong SS; Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität, Erlangen-Nürnberg, Erlangen, Germany.
  • Aung T; Department of Ophthalmology, KPNC, Redwood City, CA, USA.
  • Vithana EN; Department of Ophthalmology, School of Medicine, University of California San Francisco (UCSF), San Francisco, CA, USA.
  • Tamiya G; Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.
  • Shiga Y; Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz, Mainz, Germany.
  • Yamamoto M; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
  • Nakazawa T; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
  • Currant H; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
  • Birney E; Singapore Eye Research Institute, Singapore National Eye Certre, Singapore, Singapore.
  • Wang X; Ophthalmology & Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.
  • Auton A; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Lupton MK; Singapore Eye Research Institute, Singapore National Eye Certre, Singapore, Singapore.
  • Martin NG; Duke-National University of Singapore Medical School, Singapore, Republic of Singapore.
Nat Commun ; 12(1): 1258, 2021 02 24.
Article in En | MEDLINE | ID: mdl-33627673
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glaucoma, Open-Angle / Genome-Wide Association Study Type of study: Systematic_reviews Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glaucoma, Open-Angle / Genome-Wide Association Study Type of study: Systematic_reviews Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Country of publication: