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In Vitro Sensitivity Analysis of the Gastrointestinal Dissolution Profile of Weakly Basic Drugs in the Stomach-to-Intestine Fluid Changing System: Explanation for Variable Plasma Exposure after Oral Administration.
Takagi, Toshihide; Masada, Takato; Minami, Keiko; Kataoka, Makoto; Izutsu, Ken-Ichi; Matsui, Kazuki; Yamashita, Shinji.
Affiliation
  • Takagi T; Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
  • Masada T; Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
  • Minami K; Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
  • Kataoka M; Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
  • Izutsu KI; National Institute of Health Sciences, Kawasaki, Kanagawa 210-9501, Japan.
  • Matsui K; Sawai Pharmaceutical Co. Ltd, Osaka 532-0003, Japan.
  • Yamashita S; Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
Mol Pharm ; 18(4): 1711-1719, 2021 04 05.
Article in En | MEDLINE | ID: mdl-33629861
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Body Fluids / Gastrointestinal Absorption / Gastric Mucosa / Intestinal Mucosa Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2021 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Body Fluids / Gastrointestinal Absorption / Gastric Mucosa / Intestinal Mucosa Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2021 Document type: Article Affiliation country: Country of publication: