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A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
Zhou, Sirui; Butler-Laporte, Guillaume; Nakanishi, Tomoko; Morrison, David R; Afilalo, Jonathan; Afilalo, Marc; Laurent, Laetitia; Pietzner, Maik; Kerrison, Nicola; Zhao, Kaiqiong; Brunet-Ratnasingham, Elsa; Henry, Danielle; Kimchi, Nofar; Afrasiabi, Zaman; Rezk, Nardin; Bouab, Meriem; Petitjean, Louis; Guzman, Charlotte; Xue, Xiaoqing; Tselios, Chris; Vulesevic, Branka; Adeleye, Olumide; Abdullah, Tala; Almamlouk, Noor; Chen, Yiheng; Chassé, Michaël; Durand, Madeleine; Paterson, Clare; Normark, Johan; Frithiof, Robert; Lipcsey, Miklós; Hultström, Michael; Greenwood, Celia M T; Zeberg, Hugo; Langenberg, Claudia; Thysell, Elin; Pollak, Michael; Mooser, Vincent; Forgetta, Vincenzo; Kaufmann, Daniel E; Richards, J Brent.
Affiliation
  • Zhou S; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Butler-Laporte G; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada.
  • Nakanishi T; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Morrison DR; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada.
  • Afilalo J; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Afilalo M; Department of Human Genetics, McGill University, Montréal, Quebec, Canada.
  • Laurent L; Kyoto-McGill International Collaborative School in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Pietzner M; Research Fellow, Japan Society for the Promotion of Science, Tokyo, Japan.
  • Kerrison N; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Zhao K; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Brunet-Ratnasingham E; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada.
  • Henry D; Department of Medicine, Division of Cardiology, McGill University, Montréal, Quebec, Canada.
  • Kimchi N; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Afrasiabi Z; Department of Emergency Medicine, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Rezk N; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Bouab M; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Petitjean L; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Guzman C; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Xue X; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada.
  • Tselios C; Research Centre of the Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
  • Vulesevic B; Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montréal, Quebec, Canada.
  • Adeleye O; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Abdullah T; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Almamlouk N; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Chen Y; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Chassé M; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Durand M; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Paterson C; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Normark J; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Frithiof R; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Lipcsey M; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Hultström M; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Greenwood CMT; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Zeberg H; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Langenberg C; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
  • Thysell E; Department of Human Genetics, McGill University, Montréal, Quebec, Canada.
  • Pollak M; Research Centre of the Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
  • Mooser V; Research Centre of the Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
  • Forgetta V; SomaLogic, Inc., Boulder, CO, USA.
  • Kaufmann DE; Molecular Infection Medicine Sweden (MIMS) and Wallenberg Center for Molecular Medicine, Department of Clinical Microbiology, Section of Infection and Immunology, Umeå University, Umeå, Sweden.
  • Richards JB; Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Nat Med ; 27(4): 659-667, 2021 04.
Article in En | MEDLINE | ID: mdl-33633408
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: 2',5'-Oligoadenylate Synthetase / Genetic Predisposition to Disease / SARS-CoV-2 / COVID-19 Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2021 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: 2',5'-Oligoadenylate Synthetase / Genetic Predisposition to Disease / SARS-CoV-2 / COVID-19 Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2021 Document type: Article Affiliation country: Country of publication: