Centrosomal protein FOR20 knockout mice display embryonic lethality and left-right patterning defects.
FEBS Lett
; 595(10): 1462-1472, 2021 05.
Article
in En
| MEDLINE
| ID: mdl-33686659
ABSTRACT
Centrosomal protein FOR20 has been reported to be crucial for essential cellular processes, including ciliogenesis, cell migration, and cell cycle in vertebrates. However, the function of FOR20 during mammalian embryonic development remains unknown. To investigate the in vivo function of the For20 gene in mammals, we generated For20 homozygous knockout mice by gene targeting. Our data reveal that homozygous knockout of For20 results in significant embryonic growth arrest and lethality during gestation, while the heterozygotes show no obvious defects. The absence of For20 leads to impaired left-right patterning of embryos and reduced cilia in the embryonic node. Deletion of For20 also disrupts angiogenesis in yolk sacs and embryos. These results highlight a critical role of For20 in early mammalian embryogenesis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Deletion
/
Body Patterning
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Embryo, Mammalian
/
Embryo Loss
Limits:
Animals
Language:
En
Journal:
FEBS Lett
Year:
2021
Document type:
Article
Affiliation country: