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Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach.
Accordini, Simone; Calciano, Lucia; Johannessen, Ane; Benediktsdóttir, Bryndis; Bertelsen, Randi Jacobsen; Bråbäck, Lennart; Dharmage, Shyamali C; Forsberg, Bertil; Gómez Real, Francisco; Holloway, John W; Holm, Mathias; Janson, Christer; Jõgi, Nils O; Jõgi, Rain; Malinovschi, Andrei; Marcon, Alessandro; Martínez-Moratalla Rovira, Jesús; Sánchez-Ramos, José Luis; Schlünssen, Vivi; Torén, Kjell; Jarvis, Deborah; Svanes, Cecilie.
Affiliation
  • Accordini S; Unit of Epidemiology and Medical Statistics, Dept of Diagnostics and Public Health, University of Verona, Verona, Italy simone.accordini@univr.it.
  • Calciano L; Equal contribution as first authors.
  • Johannessen A; Unit of Epidemiology and Medical Statistics, Dept of Diagnostics and Public Health, University of Verona, Verona, Italy.
  • Benediktsdóttir B; Equal contribution as first authors.
  • Bertelsen RJ; Centre for International Health, Dept of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
  • Bråbäck L; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
  • Dharmage SC; Dept of Clinical Science, University of Bergen, Bergen, Norway.
  • Forsberg B; Oral Health Centre of Expertise in Western Norway/Vestland, Bergen, Norway.
  • Gómez Real F; Section of Sustainable Health, Dept of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
  • Holloway JW; Allergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, Australia.
  • Holm M; Section of Sustainable Health, Dept of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
  • Janson C; Dept of Clinical Science, University of Bergen, Bergen, Norway.
  • Jõgi NO; Dept of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
  • Jõgi R; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
  • Malinovschi A; Occupational and Environmental Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Marcon A; Dept of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
  • Martínez-Moratalla Rovira J; Dept of Clinical Science, University of Bergen, Bergen, Norway.
  • Sánchez-Ramos JL; Lung Clinic, Tartu University Hospital, Tartu, Estonia.
  • Schlünssen V; Lung Clinic, Tartu University Hospital, Tartu, Estonia.
  • Torén K; Dept of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden.
  • Jarvis D; Unit of Epidemiology and Medical Statistics, Dept of Diagnostics and Public Health, University of Verona, Verona, Italy.
  • Svanes C; Servicio de Neumología, Complejo Hospitalario Universitario de Albacete (CHUA), Servicio de Salud de Castilla-La Mancha (SESCAM), Albacete, Spain.
Eur Respir J ; 58(4)2021 10.
Article in En | MEDLINE | ID: mdl-33795316
ABSTRACT
Mechanistic research suggests that lifestyle and environmental factors impact respiratory health across generations by epigenetic changes transmitted through male germ cells. Evidence from studies on humans is very limited.We investigated multigeneration causal associations to estimate the causal effects of tobacco smoking on lung function within the paternal line. We analysed data from 383 adult offspring (age 18-47 years; 52.0% female) and their 274 fathers, who had participated in the European Community Respiratory Health Survey (ECRHS)/Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study and had provided valid measures of pre-bronchodilator lung function. Two counterfactual-based, multilevel mediation models were developed with paternal grandmothers' smoking in pregnancy and fathers' smoking initiation in prepuberty as exposures; fathers' forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), or FEV1/FVC z-scores as potential mediators (proxies of unobserved biological mechanisms that are true mediators); and offspring's FEV1 and FVC, or FEV1/FVC z-scores as outcomes. All effects were summarised as differences (Δ) in expected z-scores related to fathers' and grandmothers' smoking history.Fathers' smoking initiation in prepuberty had a negative direct effect on both offspring's FEV1 (Δz-score -0.36, 95% CI -0.63- -0.10) and FVC (-0.50, 95% CI -0.80- -0.20) compared with fathers' never smoking. Paternal grandmothers' smoking in pregnancy had a negative direct effect on fathers' FEV1/FVC (-0.57, 95% CI -1.09- -0.05) and a negative indirect effect on offspring's FEV1/FVC (-0.12, 95% CI -0.21- -0.03) compared with grandmothers' not smoking before fathers' birth nor during fathers' childhood.Fathers' smoking in prepuberty and paternal grandmothers' smoking in pregnancy may cause lower lung function in offspring. Our results support the concept that lifestyle-related exposures during these susceptibility periods influence the health of future generations.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tobacco Smoke Pollution Type of study: Prognostic_studies Limits: Adolescent / Adult / Child / Humans / Middle aged / Pregnancy Language: En Journal: Eur Respir J Year: 2021 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tobacco Smoke Pollution Type of study: Prognostic_studies Limits: Adolescent / Adult / Child / Humans / Middle aged / Pregnancy Language: En Journal: Eur Respir J Year: 2021 Document type: Article Affiliation country: