Your browser doesn't support javascript.
loading
Analysis of 12 GWAS-Linked Loci With Parkinson's Disease in the Chinese Han Population.
Fan, Liyuan; Shi, Changhe; Hu, Xinchao; Zhang, Zhongxian; Zheng, Huimin; Luo, Haiyang; Fan, Yu; Zhang, Shuo; Hu, Zhengwei; Yang, Jing; Mao, Chengyuan; Xu, Yuming.
Affiliation
  • Fan L; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
  • Shi C; The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
  • Hu X; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
  • Zhang Z; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
  • Zheng H; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
  • Luo H; Institute of Neuroscience, Zhengzhou University, Zhengzhou, China.
  • Fan Y; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
  • Zhang S; The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
  • Hu Z; Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
  • Yang J; The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
  • Mao C; Sino-British Research Centre for Molecular Oncology, National Centre for International Research in Cell and Gene Therapy, School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
  • Xu Y; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Front Neurol ; 12: 623913, 2021.
Article in En | MEDLINE | ID: mdl-33897588
ABSTRACT
A recent large-scale European-originated genome-wide association study identified 38 novel independent risk signals in 37 loci for Parkinson's disease (PD). However, whether these new loci are associated with PD in Asian populations remains elusive. The present study aimed to explore the relationship between the 12 most relevant loci with larger absolute values for these new risk loci and PD in the Chinese Han population. We performed a case-control study including 527 PD patients and 435 healthy controls. In the allele model, it was found that rs10748818/GBF1 was associated with PD in the Chinese Han population [p = 0.035, odds ratio (OR) 1.221, 95% confidence interval (CI) 1.014-1.472.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Observational_studies / Risk_factors_studies Language: En Journal: Front Neurol Year: 2021 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Observational_studies / Risk_factors_studies Language: En Journal: Front Neurol Year: 2021 Document type: Article Affiliation country: