CD, Crohn's disease; CFTR; CFTR, Cystic fibrosis transmembrane conductance regulator; CLC, Chloride Channel; ClC-2; DAI, Disease Activity Index; DC, Disease Control; DM, Diabetes Mellitus; DNBS, 2,4-Dinitrobenzene sulfonic acid; EtOH, Ethanol; G, Glibenclamide; GI, Gastrointestinal; GSH, Reduced Glutathione; Glibenclamide; H & E, Hematoxylin and eosin; IAEC, Institutional Animal Ethical Committee; IBD; IBD, Inflammatory Bowel Disease; L, Lubiprostone; Lubiprostone; MC, Mast cell; MDA, Malonaldehyde; MPO, Myeloperoxidase; NCEB, National Committee of Bio Ethics; PMS, Post-Mitochondrial Supernatant; RBC, Red blood cells; S, Sulfasalazine; SOD, Superoxide dismutase levels.; UC, Ulcerative colitis; WBC, White blood cells; i.p., Intraperitoneal Injection; p.o., Per Orally; s.c., Subcutaneous