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Implementing a method for engineering multivalency to substantially enhance binding of clinical trial anti-SARS-CoV-2 antibodies to wildtype spike and variants of concern proteins.
Leach, Adam; Miller, Ami; Bentley, Emma; Mattiuzzo, Giada; Thomas, Jemima; McAndrew, Craig; Van Montfort, Rob; Rabbitts, Terence.
Affiliation
  • Leach A; Institute of Cancer Research, 15 Cotswold Road, Sutton, London, SM2 5NG, UK.
  • Miller A; Institute of Cancer Research, 15 Cotswold Road, Sutton, London, SM2 5NG, UK.
  • Bentley E; Evotec, 114 Innovation Dr, Milton Park, Abingdon, OX14 4RZ, UK.
  • Mattiuzzo G; National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Hertfordshire, EN6 3QG, UK.
  • Thomas J; National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Hertfordshire, EN6 3QG, UK.
  • McAndrew C; Institute of Cancer Research, 15 Cotswold Road, Sutton, London, SM2 5NG, UK.
  • Van Montfort R; Institute of Cancer Research, 15 Cotswold Road, Sutton, London, SM2 5NG, UK.
  • Rabbitts T; Institute of Cancer Research, 15 Cotswold Road, Sutton, London, SM2 5NG, UK.
Sci Rep ; 11(1): 10475, 2021 05 18.
Article in En | MEDLINE | ID: mdl-34006961
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Single-Chain Antibodies / Spike Glycoprotein, Coronavirus / SARS-CoV-2 Limits: Humans Language: En Journal: Sci Rep Year: 2021 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Single-Chain Antibodies / Spike Glycoprotein, Coronavirus / SARS-CoV-2 Limits: Humans Language: En Journal: Sci Rep Year: 2021 Document type: Article Affiliation country: Country of publication: